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1

Novel Inhibitors of DNA Gyrase: 3D Structure Based Biased Needle Screening, Hit Validation by Biophysical Methods, and 3D Guided Optimization. A Promising Alternative to Random Screening

Boehm, Hans-Joachim, Boehringer, Markus, Bur, Daniel, Gmuender, Hans, Huber, Walter, Klaus, Werner, Kostrewa, Dirk, Kuehne, Holger, Luebbers, Thomas, Meunier-Keller, Nathalie

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 740 KB

english, 2000

2

Effect of L-carnitine on submaximal exercise metabolism after depletion of muscle glycogen

DECOMBAZ, JACQUES, DERIAZ, OLIVIER, ACHESON, KEVIN, GMUENDER, BERNARD, JEQUIER, ERIC

Journal:

Medicine & Science in Sports & Exercise

Year:

1993

File:

PDF, 711 KB

1993

3

Bringing in vitro analysis closer to in vivo : Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling

Verheijen, Marcha, Schrooders, Yannick, Gmuender, Hans, Nudischer, Ramona, Clayton, Olivia, Hynes, James, Niederer, Steven, Cordes, Henrik, Kuepfer, Lars, Kleinjans, Jos, Caiment, Florian

Journal:

Toxicology Letters

Year:

2018

Language:

english

File:

PDF, 3.14 MB

english, 2018

4

ChemInform Abstract: Design, Synthesis, and Structure—Activity Relationship Studies of ATP Analogues as DNA Gyrase Inhibitors.

Thomas Luebbers, Peter Angehrn, Hans Gmuender, Silvia Herzig, Josef Kulhanek

Journal:

Year:

2000

File:

PDF, 34 KB

2000

5

Genome-wide transcriptional analysis of bacterial genomes: applications in antibacterial drug discovery

de Saizieu, Antoine, Gmuender, Hans, Gray, Christopher, Keck, Wolfgang

Journal:

Nature Genetics

Year:

1999

Language:

english

File:

PDF, 112 KB

english, 1999

6

A New DNA Gyrase Inhibitor Subclass of the Cyclothialidine Family Based on a Bicyclic Dilactam−Lactone Scaffold. Synthesis and Antibacterial Properties

Angehrn, Peter, Goetschi, Erwin, Gmuender, Hans, Hebeisen, Paul, Hennig, Michael, Kuhn, Bernd, Luebbers, Thomas, Reindl, Peter, Ricklin, Fabienne, Schmitt-Hoffmann, Anne

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.07 MB

english, 2011

7

Cyclothialidine and its congeners: A new class of DNA gyrase inhibitors

E. Goetschi, P. Angehrn, H. Gmuender, P. Hebeisen, H. Link, R. Masciadri, J. Nielsen

Journal:

Pharmacology & Therapeutics

Year:

1993

Language:

english

File:

PDF, 799 KB

english, 1993

8

S08: The challenge of integrating different “omics” technologies

Kirstin Meyer, Laura Suter-Dick, Alexander Amberg, Jean-Charles Gautier, Maria Wendt, Bjoern Riefke, Andreas Sutter, Marian Raschke, Hans Gmuender

Journal:

Experimental and Toxicologic Pathology

Year:

2009

Language:

english

File:

PDF, 51 KB

english, 2009

9

Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies

Heidrun Ellinger-Ziegelbauer, Hans Gmuender, Arnd Bandenburg, Hans Juergen Ahr

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2008

Language:

english

File:

PDF, 812 KB

english, 2008

10

Cross-study and cross-omics comparisons of three nephrotoxic compounds reveal mechanistic insights and new candidate biomarkers

Katja A. Matheis, Emmanuelle Com, Jean-Charles Gautier, Nelson Guerreiro, Arnd Brandenburg, Hans Gmuender, Alexandra Sposny, Philip Hewitt, Alexander Amberg, Olaf Boernsen, Bjoern Riefke, Dana Hoffman

Journal:

Toxicology and Applied Pharmacology

Year:

2011

Language:

english

File:

PDF, 1.16 MB

english, 2011

11

The enhanced value of combining conventional and “omics” analyses in early assessment of drug-induced hepatobiliary injury

Heidrun Ellinger-Ziegelbauer, Melanie Adler, Alexander Amberg, Arnd Brandenburg, John J. Callanan, Susan Connor, Michael Fountoulakis, Hans Gmuender, Albrecht Gruhler, Philip Hewitt, Mark Hodson, Katj

Journal:

Toxicology and Applied Pharmacology

Year:

2011

Language:

english

File:

PDF, 2.59 MB

english, 2011

12

EU Framework 6 Project: Predictive Toxicology (PredTox)—overview and outcome

Laura Suter, Susanne Schroeder, Kirstin Meyer, Jean-Charles Gautier, Alexander Amberg, Maria Wendt, Hans Gmuender, Angela Mally, Eric Boitier, Heidrun Ellinger-Ziegelbauer, Katja Matheis, Friedlieb Pf

Journal:

Toxicology and Applied Pharmacology

Year:

2011

Language:

english

File:

PDF, 1.49 MB

english, 2011

13

A comparative integrated transcript analysis and functional characterization of differential mechanisms for induction of liver hypertrophy in the rat

Eric Boitier, Alexander Amberg, Valérie Barbié, Arne Blichenberg, Arnd Brandenburg, Hans Gmuender, Albrecht Gruhler, Diane McCarthy, Kirstin Meyer, Bjoern Riefke, Marian Raschke, Willem Schoonen, Maxi

Journal:

Toxicology and Applied Pharmacology

Year:

2011

Language:

english

File:

PDF, 1.49 MB

english, 2011

14

Combining Shapley value and statistics to the analysis of gene expression data in children exposed to air pollution

Stefano Moretti, Danitsja van Leeuwen, Hans Gmuender, Stefano Bonassi, Joost van Delft, Jos Kleinjans, Fioravante Patrone, Domenico Franco Merlo

Journal:

BMC Bioinformatics

Year:

2008

Language:

english

File:

PDF, 1.63 MB

english, 2008

15

Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens

Ramiro Dip, Sarah Lenz, Hans Gmuender, Hanspeter Naegeli

Journal:

Food and Chemical Toxicology

Year:

2009

Language:

english

File:

PDF, 1.90 MB

english, 2009

16

Transcriptomic fingerprints in human peripheral blood mononuclear cells indicative of genotoxic and non-genotoxic carcinogenic exposure

K. Hochstenbach, D.M. van Leeuwen, R.W. Gottschalk, H. Gmuender, S.B. Stølevik, U.C. Nygaard, M. Løvik, B. Granum, E. Namork, H. van Loveren, J.H.M. van Delft

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2012

Language:

english

File:

PDF, 869 KB

english, 2012

17

In vitro cytokine release from human peripheral blood mononuclear cells in the assessment of the immunotoxic potential of chemicals

S.B. Stølevik, U.C. Nygaard, E. Namork, B. Granum, A. Pellerud, D.M. van Leeuwen, H. Gmuender, J.H.M. van Delft, H. van Loveren, M. Løvik

Journal:

Toxicology in Vitro

Year:

2011

Language:

english

File:

PDF, 842 KB

english, 2011

18

Toxicogenomics and biomarker discovery for the prediction of long term toxicity

Hans Gmuender, Maria Wendt, Jochen Koenig

Journal:

Toxicology Letters

Year:

2006

Language:

english

File:

PDF, 82 KB

english, 2006

19

Characteristic expression profiles induced by carcinogens in rat liver

H. Ellinger-Ziegelbauer, H.-J. Ahr, H. Gmuender, C. Pallez, J. Koenig

Journal:

Toxicology Letters

Year:

2006

Language:

english

File:

PDF, 89 KB

english, 2006

20

Effect of dietary contaminants on in vitro cytokine release does not reflect in vivo based classification of immunotoxicity

Solvor Berntsen Stølevik, Unni Cecilie Nygaard, Ellen Namork, Berit Granum, Danitsja van Leeuwen, Hans Gmuender, Henk van Loveren, Martinus Løvik

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 90 KB

english, 2009

21

Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors

Hubschwerlen, C., Pflieger, P., Specklin, J. L., Gubernator, K., Gmuender, H., Angehrn, P., Kompis, I.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 1.66 MB

english, 1992

22

New Antibacterial Agents Derived from the DNA Gyrase Inhibitor Cyclothialidine

Angehrn, Peter, Buchmann, Stefan, Funk, Christoph, Goetschi, Erwin, Gmuender, Hans, Hebeisen, Paul, Kostrewa, Dirk, Link, Helmut, Luebbers, Thomas, Masciadri, Raffaello, Nielsen, Joergen, Reindl, Pete

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 470 KB

english, 2004

23

Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models

Doktorova, T. Y., Yildirimman, R., Vinken, M., Vilardell, M., Vanhaecke, T., Gmuender, H., Bort, R., Brolen, G., Holmgren, G., Li, R., Chesne, C., van Delft, J., Kleinjans, J., Castell, J., Bjorquist,

Journal:

Year:

2013

Language:

english

File:

PDF, 2.20 MB

english, 2013

24

Understanding the underlying mechanisms of recent Jatropha curcas L. adoption by smallholders in Kenya: A rural livelihood assessment in Bondo, Kibwezi, and Kwale districts

Mogaka, Violet, Ehrensperger, Albrecht, Iiyama, Miyuki, Birtel, Martin, Heim, Eva, Gmuender, Simon

Journal:

Energy for Sustainable Development

Year:

2014

Language:

english

File:

PDF, 712 KB

english, 2014

25

Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments

Rossnerova, Andrea, Tulupova, Elena, Tabashidze, Nana, Schmuczerova, Jana, Dostal, Miroslav, Jr, Pavel Rossner, Gmuender, Hans, Sram, Radim J.

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2013

Language:

english

File:

PDF, 936 KB

english, 2013

26

Detection of genotoxic and non-genotoxic renal carcinogens in vitro in NRK-52E cells using a transcriptomics approach

Bloch, Katarzyna M., Yaqoob, Noreen, Evans, Andrew, Radford, Robert, Jennings, Paul, Boei, Jan J. W. A, McMorrow, Tara, Slattery, Craig, Ryan, Michael P., Gmuender, Hans, van Delft, Joost H. M., Lock,

Journal:

Toxicology Research

Year:

2012

Language:

english

File:

PDF, 148 KB

english, 2012

27

[IEEE ISSCC '95 - International Solid-State Circuits Conference - San Francisco, CA, USA (15-17 Feb. 1995)] Proceedings ISSCC '95 - International Solid-State Circuits Conference - A 14-port 3.8 ns 116-word 64b read-renaming register file

Asato, C., Montoye, R., Gmuender, J., Wade Simmons, E., Ike, A., Zasio, J.

Year:

1995

Language:

english

File:

PDF, 812 KB

english, 1995

28

[IEEE ISSCC '95 - International Solid-State Circuits Conference - San Francisco, CA, USA (15-17 Feb. 1995)] Proceedings ISSCC '95 - International Solid-State Circuits Conference - A 64b 4-issue out-of-order execution RISC processor

Shen, G., Patkar, N., Ando, H., Chang, D., Chen, C., Chien Chen,, Chen, F., Forssell, P., Gmuender, J., Kitahara, T., Hungwen Li,, Lyon, D., Montoye, R., Peng, L., Savkar, S., Sherred, J., Simone, M

Year:

1995

Language:

english

File:

PDF, 902 KB

english, 1995

29

Global gene expression profiles induced by phytoestrogens in human breast cancer cells

Dip, R., Lenz, S., Antignac, J.-P., Le Bizec, B., Gmuender, H., Naegeli, H.

Journal:

Endocrine Related Cancer

Year:

2008

Language:

english

File:

PDF, 422 KB

english, 2008

30

Global Gene Expression Analysis in Cord Blood Reveals Gender-Specific Differences in Response to Carcinogenic Exposure In Utero

Hochstenbach, K., van Leeuwen, D. M., Gmuender, H., Gottschalk, R. W., Lovik, M., Granum, B., Nygaard, U., Namork, E., Kirsch-Volders, M., Decordier, I., Vande Loock, K., Besselink, H., Tornqvist, M.,

Journal:

Cancer Epidemiology Biomarkers & Prevention

Year:

2012

Language:

english

File:

PDF, 333 KB

english, 2012

31

Human Embryonic Stem Cell Derived Hepatocyte-Like Cells as a Tool for In Vitro Hazard Assessment of Chemical Carcinogenicity

Yildirimman, R., Brolen, G., Vilardell, M., Eriksson, G., Synnergren, J., Gmuender, H., Kamburov, A., Ingelman-Sundberg, M., Castell, J., Lahoz, A., Kleinjans, J., van Delft, J., Bjorquist, P., Herwig

Journal:

Toxicological Sciences

Year:

2011

Language:

english

File:

PDF, 968 KB

english, 2011

32

Transcriptomic Profile Indicative of Immunotoxic Exposure: In Vitro Studies in Peripheral Blood Mononuclear Cells

Hochstenbach, K., van Leeuwen, D. M., Gmuender, H., Stolevik, S. B., Nygaard, U. C., Lovik, M., Granum, B., Namork, E., van Delft, J. H. M., van Loveren, H.

Journal:

Toxicological Sciences

Year:

2010

Language:

english

File:

PDF, 423 KB

english, 2010

33

Toxicogenomic Profiles in Relation to Maternal Immunotoxic Exposure and Immune Functionality in Newborns

Hochstenbach, K., van Leeuwen, D. M., Gmuender, H., Gottschalk, R. W., Stolevik, S. B., Nygaard, U. C., Lovik, M., Granum, B., Namork, E., Meltzer, H. M., Kleinjans, J. C., van Delft, J. H. M., van Lo

Journal:

Toxicological Sciences

Year:

2012

Language:

english

File:

PDF, 321 KB

english, 2012

34

Carcinogens induce loss of the primary cilium in human renal proximal tubular epithelial cells independently of effects on the cell cycle

Radford, R., Slattery, C., Jennings, P., Blacque, O., Pfaller, W., Gmuender, H., Van Delft, J., Ryan, M. P., McMorrow, T.

Journal:

AJP Renal Physiology

Year:

2012

Language:

english

File:

PDF, 4.74 MB

english, 2012

35

Gene Expression Changes Triggered by Exposure of Haemophilus influenzae to Novobiocin or Ciprofloxacin: Combined Transcription and Translation Analysis

Journal:

Genome Research

Year:

2001

Language:

english

File:

PDF, 170 KB

english, 2001

36

Reduced gene expression levels after chronic exposure to high concentrations of air pollutants

Rossner, Pavel, Tulupova, Elena, Rossnerova, Andrea, Libalova, Helena, Honkova, Katerina, Gmuender, Hans, Pastorkova, Anna, Svecova, Vlasta, Topinka, Jan, Sram, Radim J.

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2015

Language:

english

File:

PDF, 1.88 MB

english, 2015

37

Transcriptomics: A New Strategy to Screen for Hazardous Contaminants in Food

Lancova, Katerina, Gmuender, Hans, Ellinger, Thomas, Naegeli, Hanspeter

Journal:

CHIMIA International Journal for Chemistry

Year:

2009

Language:

english

File:

PDF, 372 KB

english, 2009

38

diXa: a data infrastructure for chemical safety assessment

Hendrickx, D. M., Aerts, H. J. W. L., Caiment, F., Clark, D., Ebbels, T. M. D., Evelo, C. T., Gmuender, H., Hebels, D. G. A. J., Herwig, R., Hescheler, J., Jennen, D. G. J., Jetten, M. J. A., Kanterak

Journal:

Year:

2015

Language:

english

File:

PDF, 103 KB

english, 2015

39

International Biosafety and Biosecurity Challenges: Suggestions for Developing Sustainable Capacity in Low-resource Countries

Heckert, R. A., Reed, J. C., Gmuender, F. K., Ellis, M., Tonui, W.

Journal:

Applied Biosafety

Year:

2011

Language:

english

File:

PDF, 616 KB

english, 2011

40

Capsule

Gmuender, F. K.

Journal:

Applied Biosafety

Year:

2011

Language:

english

File:

PDF, 237 KB

english, 2011

41

Capsule

Gmuender, F. K.

Journal:

Applied Biosafety

Year:

2012

Language:

english

File:

PDF, 73 KB

english, 2012

42

Capsule

Gmuender, F. K.

Journal:

Applied Biosafety

Year:

2010

Language:

english

File:

PDF, 56 KB

english, 2010

43

Capsule

Gmuender, F. K.

Journal:

Applied Biosafety

Year:

2012

Language:

english

File:

PDF, 83 KB

english, 2012

44

Capsule

Gmuender, F. K.

Journal:

Applied Biosafety

Year:

2014

Language:

english

File:

PDF, 194 KB

english, 2014

45

Capsule

Gmuender, F. K.

Journal:

Applied Biosafety

Year:

2012

Language:

english

File:

PDF, 77 KB

english, 2012

46

Capsule

Gmuender, F. K.

Journal:

Applied Biosafety

Year:

2013

Language:

english

File:

PDF, 387 KB

english, 2013

47

Capsule

Gmuender, F. K.

Journal:

Applied Biosafety

Year:

2012

Language:

english

File:

PDF, 92 KB

english, 2012

48

Capsule

Gmuender, F. K.

Journal:

Applied Biosafety

Year:

2010

Language:

english

File:

PDF, 65 KB

english, 2010

49

Capsule

Gmuender, F. K.

Journal:

Applied Biosafety

Year:

2011

Language:

english

File:

PDF, 58 KB

english, 2011

50

Capsule

Gmuender, F. K.

Journal:

Applied Biosafety

Year:

2013

Language:

english

File:

PDF, 68 KB

english, 2013

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